STUDY OF BIOLOGICAL ACTIVITY OF DOXORUBICIN CONJUGATE WITH NACETYL-D-GALACTOSAMINE HYDRASONIC LINKER

Molecules containing the N-acetylgalactosamine residue are capable to bind to the asialoglycoprotein receptor, a protein presented on the surface of the liver tumor cells; therefore it is suggested that doxorubicin conjugates containing such fragment can be delivered to hepatocellular carcinoma cells as target, and then, upon hydrazone link splitting, in acidic environment of the tumor release the active substance.