Microstructure design for bone void filler

Bone void fillers are used to fill in the empty space within bone defect. The use of fillers is aiming to reduce the time required for healing the defect. The filler should show the resistance to washout and the ability of adsorption within human body. In the present study, a microstructure design approach is employed to evaluate the performance of bone void filler. The microstructure features, such as the contacts between particles, the size of pores, and their interconnectivity, are considered. The pellets composing of these microstructure features are prepared for in vitro and in vivo evaluations. The type of contacts between resorbable particles plays a key role on washout resistance. The interconnectivity of pores affects significantly on the absorption rate in vivo. Through the control of these microstructure characteristics, the resorbable behavior of bone void filler can be tailored.