TINU syndrome

Tubulointerstitial nephritis and uveitis (TINU) syndrome is defined as the association of tubulointerstitial nephritis (TIN) and uveitis in a patient without any other systemic disease that can cause this overlap of ocular and renal inflammation. Commonly, ocular involvement consists in a sudden‐onset bilateral non‐granulomatous anterior uveitis. However, it is becoming clear that non‐granulomatous anterior uveitis is not the only uveitis phenotype associated with TINU syndrome. It is likely that this uveitis aetiology is underestimated as nephritis is most of the time self‐limited. Although a reliable diagnosis of TIN can be made from clinical and laboratory findings, renal biopsy is required for its definitive diagnosis. On the other hand, the increase of urinary β‐2 microglobulin and serum creatine level has been proposed as a potential tool to screen and follow nephritis in TINU syndrome. The main purpose of this presentation is to clarify the assessment in case of TINU syndrome suspicion, to describe the associated uveitis as well as the management.