Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage

Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage

In this report, we evaluated the effects of selenylated indoles ( 3a-d ) on lipid membranes and their capacity to interact with DNA. These selenylated indoles increased the motion rate of the polar region of lipids and compounds 3b-d ordered the non-polar region. The DNA cleavage ability was observe...

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Veröffentlicht in:New journal of chemistry 2023-02, Vol.47 (6), p.2719-2726
Hauptverfasser: Pedroso, Gabriela J, Costa, Desirée M. S, Felipe Kokuszi, Lucas T, da Silva, Eduardo B. V, Cavalcante, Marcos F. O, Junca, Eduardo, Moraes, Cassio A. O, Pich, Claus T, de Lima, Vânia R, Saba, Sumbal, Rafique, Jamal, Frizon, Tiago E. A
Format: Artikel
Sprache:eng
Schlagworte:
Cleavage
Indoles
Lipids
Membranes
Polar environments
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Beschreibung
Zusammenfassung:In this report, we evaluated the effects of selenylated indoles ( 3a-d ) on lipid membranes and their capacity to interact with DNA. These selenylated indoles increased the motion rate of the polar region of lipids and compounds 3b-d ordered the non-polar region. The DNA cleavage ability was observed only for 3c . Selenylated indoles increased the motion rate of the polar region of lipids and ordered the non-polar region, presenting DNA cleavage ability.
ISSN:1144-0546
1369-9261
DOI:10.1039/d2nj04330k