Role of Sphingolipid Metabolism Played in Neurodegenerative Disease: A Descriptive Review

Sphingolipid comprise an important group of biomolecules, some of which have been shown to play important roles in the neurodegenerative disease and regulation of many cell functions. Sphingolipid are a ubiquitous membrane lipid present in every cell & found most abundantly in neural tissue. Sphingolipid metabolism alterations in the neurodegenerative disease. It appears that alteration in the gene expression pattern in these disease conditions are biased to manipulate the system in order to result in a particular disease. The pathogenesis of AD is highly linked to Amyloid beta deposition & oxidative stress. We report that alterations in Sphingolipid metabolism during normal brain aging and in the brain of AD patients. In the Parkinson’s disease the enzyme which degrades the glycolipid glucosylceramide (GlcCer) is encoded by a gene known as glucocerebrosidase-1 (GBA1) which is one of the hallmarks in the pathology of PD