Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo

Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo

Pt(terpyridine) complexes are well-known DNA intercalators. The introduction of an NHC co-ligand rendered such a complex highly antiproliferative in cancer cells compared to its chlorido derivative. Despite the high potency, zebrafish embryos tolerated the compound well, especially compared to cispl...

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Veröffentlicht in:Dalton transactions : an international journal of inorganic chemistry 2023-01, Vol.52 (5), p.1388-1392
Hauptverfasser: Sullivan, Matthew P, Adams, Muneebah, Riisom, Mie, Herbert, Caitlin D, Tong, Kelvin K H, Astin, Jonathan W, Jamieson, Stephen M F, Hanif, Muhammad, Goldstone, David C, Hartinger, Christian G
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - pharmacology
Antiproliferatives
Biocompatibility
Cell Line, Tumor
DNA
Ligands
Platinum
Toxicity
Zebrafish
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Zusammenfassung:Pt(terpyridine) complexes are well-known DNA intercalators. The introduction of an NHC co-ligand rendered such a complex highly antiproliferative in cancer cells compared to its chlorido derivative. Despite the high potency, zebrafish embryos tolerated the compound well, especially compared to cisplatin. DNA interaction studies support a mode of action related to intercalation.
ISSN:1477-9226
1477-9234
DOI:10.1039/d2dt02539f