In silico analysis of the potential of Sargassum sp brewed and Syzygium polyanthum leaf as nutraceuticals

The Covid-19 pandemic is causing a major public health crisis. One of the efforts that can be done is with protection from within the body by having a strong immune system. The immunity can be increased by consuming high antioxidant compounds comes from Sargassum sp brown seaweed and Syzygium polyanthum leaf. This study aims to determine the bioactive potential of Sargassum sp brewed and Syzygium polyanthum leaf using in silico analysis. The method used was GC-MS analysis to obtain chemical profiles and in silico analysis (prediction of activity spectra for biologically active substances) PASS server, SwissADME, Pro Tox II). GC-MS analysis with screen quality above 85% obtained 6 (six) compounds from Sargassum sp brewed and Syzygium polyanthum (SBSP), namely Pentane (69.12 %), 2-undecanone (3.80 %), Nerolidol (2.25 %), Biphenyl (8.50 %), Methylisoeugenol (13.08 %), 1-phenanthrenecarboxylic acid (3.26 %). Based on the PASS server, these small molecules can be antivirals, anti-inflammatory, antineoplastic, immunostimulant, antihypertensive antimutagenic, and anticholesterol. All small molecules have good drug-likeness potential, absorption, distribution, metabolism, excretion, and toxicity in the body based on in silico analysis (SwissADME and Pro Tox II). It can be the basis for developing nutraceuticals to increase immunity and prevent exposure to Covid-19.