Identification of three novel new psychoactive substances 4F‐AB‐BUTINACA, AB‐PHETINACA, and 2F‐NENDCK

The identification of new psychoactive substances (NPS) is an active and cutting‐edge topic in forensic science. With the emergence of a large number of NPS, their timely identification to prevent spread can pose a challenge to clinical and forensic toxicology laboratories. Three emerging NPS had been identified in recently seized materials, including two synthetic cannabinoids [N‐(1‐amino‐3‐methyl‐1‐oxobutan‐2‐yl)‐1‐(4‐fluorobutyl)‐1H‐indazole‐3‐carboxamide (4F‐AB‐BUTINACA) and N‐(1‐amino‐3‐methyl‐1‐oxobutan‐2‐yl)‐1‐phenethyl‐1H‐indazole‐3‐carboxamide (AB‐PHETINACA)] and a ketamine‐like substance [2‐(2‐fluorophenyl)‐2‐(ethylamino) cyclohexan‐1‐one(2F‐NENDCK)]. The three compounds were first identified by Fourier transform infrared spectrometry (FT‐IR), gas chromatography–mass spectrometry (GC–MS), ultrahigh‐performance liquid chromatography‐quadrupole time‐of‐flight‐mass spectrometry (UHPLC‐QTOF‐MS), and nuclear magnetic resonance (NMR). These data may assist forensic analysts in analyzing the same substances or their homologous compounds. Three novel new psychoactive substances 4F‐AB‐BUTINACA, AB‐PHETINACA and 2F‐NENDCK were identified. And for the first time, their FT‐IR, GC–MS, UHPLC‐QTOF‐MS and NMR spectra were analyzed and reported.