Sleep and Quality of Life in Relation to Dialysis Adequacy in Chronic Kidney Disease Patients Undergoing Hemodialysis

Background: Adequate clearance contributes to improving the quality of life and sleep of patients with End-Stage Chronic Kidney Disease (CKD). The aim of the study was to investigate the correlation between dialysis adequacy, sleep quality and quality of life in patients undergoing a chronic hemodialysis program. Methodology: The study was conducted among 352 patients with CKD. Quality of life was assessed using the kidney disease and Quality of Life (KDQOL-SF™) questionnaire, and sleep quality with the Pittsburgh questionnaire. Hematological indices were also taken to calculate the adequacy of clearance and their correlation with their quality of life as well as with sleep. Results: The Kt/V ratio was greater in patients who had better sleep quality and was associated with patients' quality of life and all of its dimensions. 82.7% of patients had poor sleep quality. Good sleep quality was positively associated with both physical and mental health scales as well as physical and cognitive functioning, vitality, social and emotional role, while overall quality of life was negatively associated with poor sleep quality. MDRD creatinine clearance was negatively associated with the physical health scale, while no significant correlation was observed between the mental health scale and global quality of life and MDRD creatinine clearance or CKD-EPI Conclusions: The quality of sleep was correlated with the quality of life of the patients. Providing adequate dialysis significantly contributes to improving and maintaining the level of quality of life and sleep as a key component of the quality of life of CKD patients undergoing hemodialysis and consequently in the reduced morbidity and mortality of these patients.