Lactiplantibacillus plantarum L67 probiotics vs paraprobiotics for reducing pro‐inflammatory responses in colitis mice

Probiotics improve intestinal symptoms and reduce damage in patients with inflammatory bowel disease (IBD). However, live bacteria are not consistently effective for IBD patients because of their weaker immune system and damaged intestinal epithelial cells. This study compared the suppression effect of probiotic (L67) and paraprobiotic Lactiplantibacillus plantarum L67 (PPL67) cells on dextran sulphate sodium (DSS)‐treated Institute of Cancer Research mice. The results showed that the administration of PPL67 to DSS‐treated mice mitigated the symptoms of colitis as evidenced by reductions in DAI define levels and the pro‐inflammatory factors. So, these results indicate that L. plantarum L67 may prevent the pathogenesis of chronic colitis in a safer and more stable way. L.plantarum L67 reduces pro‐inflammatory responses in colitis mice.