Antibacterial activity of Gorgonian coral Junceella associated bacteria against catheter associated urinary tract infection (CAUTI) pathogens isolated from Karimunjawa Marine National Park, Java Sea, Indonesia

Catheter-associated urinary tract infection (CAUTI) is the most common nosocomial infection in hospitals worldwide. CAUTI treatment using antibiotics leads to the resistance of pathogenic bacteria against several classes of antibiotics. Hence, the search for new antibiotic compounds is carried out continuously. This research aimed to obtain the Gorgonian coral Junceella associated bacteria with antibacterial activity against CAUTI pathogens. The antipathogenic assay using the agar plug method showed that 2 of the 14 isolates, SA19.2 and SA19.3, had activity against Escherichia coli and Klebsiella pneumoniae. Detection of biosynthetic gene clusters indicated the presence of the NRPS gene in both active isolates. The 16S rRNA gene sequence analyses showed that SA.19.2 and SA.19.3 isolates were closely related to Micrococcus yunnanensis.