Systemic medications and implant success: Is there a link? Part three The effects of antiresorptive and anti-angiogenic agents on the outcome of implant therapy

Dental implants require healthy bone for successful osseointegration. However, bone health can become compromised by aging and/or the presence of underlying medical conditions. The severity and complications associated with these medical conditions usually indicate that they require medication for successful management. Some of these medications may undoubtedly exert effects on bone through direct or indirect mechanisms and, therefore, may also affect osseointegration. These include antihypertensive drugs, oral hypoglycemic agents/insulin, hormones (corticosteroid, thyroxin, and tamoxifen), and antiresorptive agents, including bisphosphonates and anti-angiogenic agents. Part three of this paper reviews the current knowledge regarding the effects of antiresorptive agents on the outcome of implant therapy.