Construction of a predictive model for the risk of new-onset overt hepatic encephalopathy after admission in patients with hepatitis B-related acute-on-chronic liver failure

Objective To explore the factors influencing hospitalized new-onset overt hepatic encephalopathy (OHE) in hospitalized patients with hepatitis B-associated acute-on-chronic liver failure (HBV-ACLF), and to construct an individualized risk prediction model. Methods A total of 310 HBV-ACLF patients admitted to Mengchao Hepatobiliary Hospital of Fujian Medical University from December 2016 to December 2020 were selected, and divided into non-hepatic encephalopathy group (n=236), hepatic encephalopathy group (n=74) according to whether OHE occurred after admission. The general data, laboratory test indicators, and model of end-stage liver disease (MELD) scores were compared between the two groups; univariate and multivariate logistic regressions were used to analyze the factors influencing the hospitalized new-onset OHE in HBV-ACLF patients after admission. A nomogram model was constructed with the influencing factors. The receiver operating characteristic (ROC) curve and the calibration curve was used to evaluat