Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats
The aim of this study was to investigate the protective effects of telmisartan and/or pyridoxamine on spontaneously hypertensive rats (SHRs). Rats were treated with telmisartan (T group) or pyridoxamine (P group), or telmisartan and pyridoxamine (TP group). The serum levels of advanced glycation end...
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| Veröffentlicht in: | Molecular medicine reports 2012-03, Vol.5 (3), p.655-662 |
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| creator | Zhu, Pengli Lin, Hong Sun, Chengai Lin, Fan Yu, Huizhen Zhuo, Xiuping Zhou, Chanjuan Deng, Zhisheng |
| description | The aim of this study was to investigate the protective effects of telmisartan and/or pyridoxamine on spontaneously hypertensive rats (SHRs). Rats were treated with telmisartan (T group) or pyridoxamine (P group), or telmisartan and pyridoxamine (TP group). The serum levels of advanced glycation end products (AGEs), superoxide dismutase (SOD), malonaldehyde and the level of 24-h urinary albumin were measured. Morphological changes in renal tissues were observed under light (H&E or Masson's trichrome) and transmission electron microscopy. Expression of NF-κBp65 and p-ERK1/2 in renal tissue was detected by immunohistochemistry. Expression of receptors for advanced glycation end products (RAGE) and TGF-β in the renal cortex was investigated by western blotting. We found that early renal structural and functional damage was alleviated in the three intervention groups. SOD activity was significantly elevated in the P and TP groups (P |
| doi_str_mv | 10.3892/mmr.2011.717 |
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Rats were treated with telmisartan (T group) or pyridoxamine (P group), or telmisartan and pyridoxamine (TP group). The serum levels of advanced glycation end products (AGEs), superoxide dismutase (SOD), malonaldehyde and the level of 24-h urinary albumin were measured. Morphological changes in renal tissues were observed under light (H&E or Masson's trichrome) and transmission electron microscopy. Expression of NF-κBp65 and p-ERK1/2 in renal tissue was detected by immunohistochemistry. Expression of receptors for advanced glycation end products (RAGE) and TGF-β in the renal cortex was investigated by western blotting. We found that early renal structural and functional damage was alleviated in the three intervention groups. SOD activity was significantly elevated in the P and TP groups (P<0.05) compared to that in the T group. Of note, both the positive expression of NF-κBp65 (P<0.01 vs. the T and P groups) and p-ERK1/2 (P<0.05 vs. the P group) was lowest in the TP group. Our results suggest that the combined use of telmisartan and pyridoxamine is superior to the single use of either drug on renoprotection, which may result from the alleviation of oxidative stress and the reduction of NF-κBp65 and p-ERK1/2 activation.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2011.717</identifier><identifier>PMID: 22200727</identifier><language>eng</language><publisher>Greece: Spandidos Publications UK Ltd</publisher><subject>Advanced glycosylation end products ; Animals ; Antibodies ; Antigens ; Benzimidazoles - pharmacology ; Benzoates - pharmacology ; Bioengineering ; Blood pressure ; Drug Synergism ; Endocrine system ; Gastric lavage ; Glycation End Products, Advanced - blood ; Glycosylation ; Hypertension ; Immunohistochemistry ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Laboratory animals ; Male ; Malondialdehyde ; Malondialdehyde - analysis ; Malondialdehyde - blood ; Medical research ; Mitogen-Activated Protein Kinase 1 - metabolism ; Mitogen-Activated Protein Kinase 3 - metabolism ; Oxidative stress ; Protective Agents - pharmacology ; Proteins ; Pyridoxamine - pharmacology ; Rats ; Rats, Inbred SHR ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic - metabolism ; Renal cortex ; Serum levels ; Signal transduction ; Structure-function relationships ; Superoxide dismutase ; Superoxide Dismutase - blood ; Transcription Factor RelA - metabolism ; Transforming Growth Factor beta - metabolism ; Transmission electron microscopy ; Variance analysis ; Western blotting</subject><ispartof>Molecular medicine reports, 2012-03, Vol.5 (3), p.655-662</ispartof><rights>Copyright Spandidos Publications UK Ltd. 2012</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-1e346d04ecf9c57521077677b8f2c3f71cdd1cc7fe550bb02bbe3cd3257f89413</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22200727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Pengli</creatorcontrib><creatorcontrib>Lin, Hong</creatorcontrib><creatorcontrib>Sun, Chengai</creatorcontrib><creatorcontrib>Lin, Fan</creatorcontrib><creatorcontrib>Yu, Huizhen</creatorcontrib><creatorcontrib>Zhuo, Xiuping</creatorcontrib><creatorcontrib>Zhou, Chanjuan</creatorcontrib><creatorcontrib>Deng, Zhisheng</creatorcontrib><title>Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>The aim of this study was to investigate the protective effects of telmisartan and/or pyridoxamine on spontaneously hypertensive rats (SHRs). Rats were treated with telmisartan (T group) or pyridoxamine (P group), or telmisartan and pyridoxamine (TP group). The serum levels of advanced glycation end products (AGEs), superoxide dismutase (SOD), malonaldehyde and the level of 24-h urinary albumin were measured. Morphological changes in renal tissues were observed under light (H&E or Masson's trichrome) and transmission electron microscopy. Expression of NF-κBp65 and p-ERK1/2 in renal tissue was detected by immunohistochemistry. Expression of receptors for advanced glycation end products (RAGE) and TGF-β in the renal cortex was investigated by western blotting. We found that early renal structural and functional damage was alleviated in the three intervention groups. SOD activity was significantly elevated in the P and TP groups (P<0.05) compared to that in the T group. Of note, both the positive expression of NF-κBp65 (P<0.01 vs. the T and P groups) and p-ERK1/2 (P<0.05 vs. the P group) was lowest in the TP group. Our results suggest that the combined use of telmisartan and pyridoxamine is superior to the single use of either drug on renoprotection, which may result from the alleviation of oxidative stress and the reduction of NF-κBp65 and p-ERK1/2 activation.</description><subject>Advanced glycosylation end products</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Benzimidazoles - pharmacology</subject><subject>Benzoates - pharmacology</subject><subject>Bioengineering</subject><subject>Blood pressure</subject><subject>Drug Synergism</subject><subject>Endocrine system</subject><subject>Gastric lavage</subject><subject>Glycation End Products, Advanced - blood</subject><subject>Glycosylation</subject><subject>Hypertension</subject><subject>Immunohistochemistry</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - analysis</subject><subject>Malondialdehyde - blood</subject><subject>Medical research</subject><subject>Mitogen-Activated Protein Kinase 1 - metabolism</subject><subject>Mitogen-Activated Protein Kinase 3 - metabolism</subject><subject>Oxidative stress</subject><subject>Protective Agents - pharmacology</subject><subject>Proteins</subject><subject>Pyridoxamine - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Receptor for Advanced Glycation End Products</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Renal cortex</subject><subject>Serum levels</subject><subject>Signal transduction</subject><subject>Structure-function relationships</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - blood</subject><subject>Transcription Factor RelA - metabolism</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Transmission electron microscopy</subject><subject>Variance analysis</subject><subject>Western blotting</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNo9kE1LxDAQhoMo7rp68ywBr3bNR9Nsj7L4BQse1HNIk8mapU1r0or993Zx9TQD87wvw4PQJSVLvirZbdPEJSOULiWVR2hOZUkzTkh-fNhZWcoZOktpR0ghmChP0YwxRohkco7q1zFA3PrUe4PBOTB9wq3DPdSNTzr2OmAdLO7G6G37rRsfALcBg471iCMEXWOrG70F7ANOXRumBLRDmq4fYwexh5D8F-Co-3SOTpyuE1wc5gK9P9y_rZ-yzcvj8_pukxkuij6jwPPCkhyMK42QglEiZSFltXLMcCepsZYaIx0IQaqKsKoCbixnQrpVmVO-QNe_vV1sPwdIvdq1Q5xeTYrJQvBclkU-UTe_lIltShGc6qJvdBwVJWqvVk1q1V6tmtRO-NWhdKgasP_wn0v-A_SIduQ</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Zhu, Pengli</creator><creator>Lin, Hong</creator><creator>Sun, Chengai</creator><creator>Lin, Fan</creator><creator>Yu, Huizhen</creator><creator>Zhuo, Xiuping</creator><creator>Zhou, Chanjuan</creator><creator>Deng, Zhisheng</creator><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20120301</creationdate><title>Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats</title><author>Zhu, Pengli ; Lin, Hong ; Sun, Chengai ; Lin, Fan ; Yu, Huizhen ; Zhuo, Xiuping ; Zhou, Chanjuan ; Deng, Zhisheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-1e346d04ecf9c57521077677b8f2c3f71cdd1cc7fe550bb02bbe3cd3257f89413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Advanced glycosylation end products</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Benzimidazoles - pharmacology</topic><topic>Benzoates - pharmacology</topic><topic>Bioengineering</topic><topic>Blood pressure</topic><topic>Drug Synergism</topic><topic>Endocrine system</topic><topic>Gastric lavage</topic><topic>Glycation End Products, Advanced - blood</topic><topic>Glycosylation</topic><topic>Hypertension</topic><topic>Immunohistochemistry</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - analysis</topic><topic>Malondialdehyde - blood</topic><topic>Medical research</topic><topic>Mitogen-Activated Protein Kinase 1 - metabolism</topic><topic>Mitogen-Activated Protein Kinase 3 - metabolism</topic><topic>Oxidative stress</topic><topic>Protective Agents - pharmacology</topic><topic>Proteins</topic><topic>Pyridoxamine - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Receptor for Advanced Glycation End Products</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Renal cortex</topic><topic>Serum levels</topic><topic>Signal transduction</topic><topic>Structure-function relationships</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - blood</topic><topic>Transcription Factor RelA - metabolism</topic><topic>Transforming Growth Factor beta - metabolism</topic><topic>Transmission electron microscopy</topic><topic>Variance analysis</topic><topic>Western blotting</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Pengli</creatorcontrib><creatorcontrib>Lin, Hong</creatorcontrib><creatorcontrib>Sun, Chengai</creatorcontrib><creatorcontrib>Lin, Fan</creatorcontrib><creatorcontrib>Yu, Huizhen</creatorcontrib><creatorcontrib>Zhuo, Xiuping</creatorcontrib><creatorcontrib>Zhou, Chanjuan</creatorcontrib><creatorcontrib>Deng, Zhisheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Pengli</au><au>Lin, Hong</au><au>Sun, Chengai</au><au>Lin, Fan</au><au>Yu, Huizhen</au><au>Zhuo, Xiuping</au><au>Zhou, Chanjuan</au><au>Deng, Zhisheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>5</volume><issue>3</issue><spage>655</spage><epage>662</epage><pages>655-662</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>The aim of this study was to investigate the protective effects of telmisartan and/or pyridoxamine on spontaneously hypertensive rats (SHRs). Rats were treated with telmisartan (T group) or pyridoxamine (P group), or telmisartan and pyridoxamine (TP group). The serum levels of advanced glycation end products (AGEs), superoxide dismutase (SOD), malonaldehyde and the level of 24-h urinary albumin were measured. Morphological changes in renal tissues were observed under light (H&E or Masson's trichrome) and transmission electron microscopy. Expression of NF-κBp65 and p-ERK1/2 in renal tissue was detected by immunohistochemistry. Expression of receptors for advanced glycation end products (RAGE) and TGF-β in the renal cortex was investigated by western blotting. We found that early renal structural and functional damage was alleviated in the three intervention groups. SOD activity was significantly elevated in the P and TP groups (P<0.05) compared to that in the T group. Of note, both the positive expression of NF-κBp65 (P<0.01 vs. the T and P groups) and p-ERK1/2 (P<0.05 vs. the P group) was lowest in the TP group. Our results suggest that the combined use of telmisartan and pyridoxamine is superior to the single use of either drug on renoprotection, which may result from the alleviation of oxidative stress and the reduction of NF-κBp65 and p-ERK1/2 activation.</abstract><cop>Greece</cop><pub>Spandidos Publications UK Ltd</pub><pmid>22200727</pmid><doi>10.3892/mmr.2011.717</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Advanced glycosylation end products Animals Antibodies Antigens Benzimidazoles - pharmacology Benzoates - pharmacology Bioengineering Blood pressure Drug Synergism Endocrine system Gastric lavage Glycation End Products, Advanced - blood Glycosylation Hypertension Immunohistochemistry Kidney - drug effects Kidney - metabolism Kidney - pathology Laboratory animals Male Malondialdehyde Malondialdehyde - analysis Malondialdehyde - blood Medical research Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Oxidative stress Protective Agents - pharmacology Proteins Pyridoxamine - pharmacology Rats Rats, Inbred SHR Receptor for Advanced Glycation End Products Receptors, Immunologic - metabolism Renal cortex Serum levels Signal transduction Structure-function relationships Superoxide dismutase Superoxide Dismutase - blood Transcription Factor RelA - metabolism Transforming Growth Factor beta - metabolism Transmission electron microscopy Variance analysis Western blotting |
| title | Synergistic effects of telmisartan and pyridoxamine on early renal damage in spontaneously hypertensive rats |
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