Asymmetric Pd(II)‐Catalyzed C−O, C−N, C−C Bond Formation Using Alkenes as Substrates: Insight into Recent Enantioselective Developments

This Review summarizes the advances in the catalytic enantioselective mono‐ and difunctionalization of alkenes, highlighting the fundamental role of ligands. Several types of asymmetric reactions have been developed involving different bonds formation, C−O, C−N and C−C, highlighting the urgency to go ahead in the search for new ligands and synthetic methodologies in order to improve the control over the reaction selectivity and activity and thus, to increase the applications in the synthesis of heterocyclic scaffolds and biologically active compounds. The Review is organized into paragraphs, which discuss the type of bond formed during the nucleopalladation, C−O, C−N, C−C bonds, and the type of reaction involved. Recent advances in Pd(II)‐catalyzed enantioselective mono‐ and difunctionalization of alkenes, involving C−O, C−N and C−C bond formation, are discussed, highlighting the fundamental role of ligands and reaction conditions optimization. This review summarizes the significant advances made over the last years and provides tools for developing new enantioselective transformations.