Formulation and characterization of Sauropus androgynous (L) Merr leaf extract Gel in Combination with CMC-Na and Carbopol 940 Using DPPH Method

Introduction: Katuk Leaf (Sauropus androgynus L. Merr.) from Kupang, East Nusa Tenggara, Indonesia is a type of plant that contains chalcone which is used as an antioxidant. This study aims to formulate a gel preparation from Katuk Leaf extract using various concentrations of CMC-Na and carbopol 940, to see the stability of the physical properties of the Katuk leaf extract gel Sauropus androgynus (L.) Merr. Methods: Katuk Leaf Extract was obtained by percolation method using 70% ethanol as solvent. The gels were made in formulas 1, 2, 3, 4, and 5 with a concentration of CMC-Na and carbopol 940 at 0:10; 1:9; 2:8; 9:1; 10:0 ratio. Antioxidant activity was tested with DPPH, observed for its physical stability including organoleptic, homogeneity, viscosity, pH dispersion, adhesion, and gel stability using the process of freeze thaw action. Results: The results showed that the concentration of carbopol 940 increased viscosity and adhesion and decreased dispersion and pH, while CMC-Na increased dispersion and pH and decreased viscosity and adhesion in the physical properties of the Katuk Leaf extract gel. Test results with IC50 extracts of Katuk Leaves at 73.815 ppm, showed that the formula 3 with a concentration of carbopol 940 and CMC-Na at 2: 8 percent by ratio, is a gel with antioxidant activity being most effective with the value of the IC50 100.814. Conclusion:So, it can be concluded that the stability of the physical properties of the gel shows the formula 3 with concentration carbopol 940 and CMC-Na at 2%: 8% gel with the best stability of physical properties.