Studying the Anti-Cancer Activity of Resveratrol 1,3,4-Thiadiazol Derivatives
The used Resveratrol-Thiadiazol derivatives (A, B, C) were prepared and characterized by 1H-13C NMR and FT-IR spectroscopies. This study used two cell lines for cytotoxicity testing: MCF-7 (Human Breast Cancer Cells) and WRL-68 (Human Normal Liver Cells), The result of anticancer study showed that...
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| Veröffentlicht in: | Research journal of pharmacy and technology 2022-10, Vol.15 (10), p.4377-4381 |
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| creator | Abdul-Majeed, Shahlaa Zuhair Hamood, Sarah A. Dawood, Ashour H. |
| description | The used Resveratrol-Thiadiazol derivatives (A, B, C) were prepared and characterized by 1H-13C NMR and FT-IR spectroscopies. This study used two cell lines for cytotoxicity testing: MCF-7 (Human Breast Cancer Cells) and WRL-68 (Human Normal Liver Cells), The result of anticancer study showed that derivative C had significant selectivity on MCF-7 used in this study even in very low concentration used to evaluate the anticancer activity while derivatives A and B showed non-significant selectivity on MCF-7 in low concentration while in high concentration showed small selectivity which may be negligible, this selectivity determined according to the comparison between: MCF-7 (Human Breast Cancer Cells) and WRL-68 (Human Normal Liver Cells). |
| doi_str_mv | 10.52711/0974-360X.2022.00734 |
| format | Article |
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| ispartof | Research journal of pharmacy and technology, 2022-10, Vol.15 (10), p.4377-4381 |
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| subjects | Breast cancer Cell cycle Cytotoxicity Ethanol Potash Potassium Solvents Sulfur |
| title | Studying the Anti-Cancer Activity of Resveratrol 1,3,4-Thiadiazol Derivatives |
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