Studying the Anti-Cancer Activity of Resveratrol 1,3,4-Thiadiazol ‎Derivatives

The used Resveratrol-Thiadiazol derivatives (A, B, C) were prepared and characterized by 1H-13C NMR and FT-IR spectroscopies. This study used two cell lines for cytotoxicity testing: ‎MCF-7 (Human Breast Cancer Cells) and WRL-68 (Human Normal Liver Cells), The result of anticancer study showed ‎that derivative C had significant selectivity on MCF-7 used in this study even in very low concentration used to evaluate ‎the anticancer activity while derivatives A and B showed non-significant selectivity on MCF-7 in low concentration while ‎in high concentration showed small selectivity which may be negligible, this selectivity determined according to the ‎comparison between: MCF-7 (Human Breast Cancer Cells) and WRL-68 (Human Normal Liver Cells).‎