Reaction of 6-Oxocyclohexane-1,3-dicarboxamides with Binucleophilic Reagents. Antinociceptive Activity of the Synthesized Hydrazones and 2,3,4,5,6,7-Hexahydro-1H-indazoles
Novel hydrazones and hexahydro-1 H -indazole-5-carboxamides were obtained via the reaction of 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides with tosylhydrazide, 2,4-dinitrophenylhydrazine, and phenylhydrazine, respectively. The structures of the products were proved by IR and 1 H and...
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| Veröffentlicht in: | Russian journal of organic chemistry 2022-11, Vol.58 (11), p.1610-1616 |
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| container_title | Russian journal of organic chemistry |
| container_volume | 58 |
| creator | Gein, V. L. Lezhnina, D. D. Nosova, N. V. Makhmudov, R.R. Dmitriev, M. V. |
| description | Novel hydrazones and hexahydro-1
H
-indazole-5-carboxamides were obtained via the reaction of 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides with tosylhydrazide, 2,4-dinitrophenylhydrazine, and phenylhydrazine, respectively. The structures of the products were proved by IR and
1
H and
13
C NMR spectroscopy, as well as X-ray diffraction analysis. The synthesized compounds were tested for antinociceptive activity. |
| doi_str_mv | 10.1134/S1070428022110070 |
| format | Article |
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H
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1
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13
C NMR spectroscopy, as well as X-ray diffraction analysis. The synthesized compounds were tested for antinociceptive activity.</description><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Hydrazones</subject><subject>NMR spectroscopy</subject><subject>Organic Chemistry</subject><subject>Reagents</subject><issn>1070-4280</issn><issn>1608-3393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kUFP3DAQhaOKSgXaH9CbpV5jGNuJkxy3qHSRkJBKe44ce0KMgr21vbDhL_En69UicUA9vdHMe987TFF8ZXDGmKjObxk0UPEWOGcM8vyhOGYSWipEJ47ynFd0f_9UnMR4DwAVq8Rx8fILlU7WO-JHIunNzutFz37CnXJIWSmosVqFwe_UgzUYyZNNE_lu3VbP6DeTna0mmXGHLsUzsnLJOq-txk2yj0hWmf1o07KnpwnJ7eKyRPuMhqwXE9SzdxmqnCG8FGVV1qUsG7rO9VM-e8rW1DqTbTPGz8XHUc0Rv7zqafHn8sfvizW9vvl5dbG6pprLNlElhBzbQUnRAPKhZR1DDbXpVDMMAkeOXKIBUykwomnkWGOlVdMpDSAHqMVp8e3A3QT_d4sx9fd-G1yu7HlTt4zXotu72MGlg48x4Nhvgn1QYekZ9Puf9O9-kjP8kInZ6-4wvJH_H_oHC-iO9g</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Gein, V. L.</creator><creator>Lezhnina, D. D.</creator><creator>Nosova, N. V.</creator><creator>Makhmudov, R.R.</creator><creator>Dmitriev, M. V.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-8512-0399</orcidid><orcidid>https://orcid.org/0000-0002-2326-3976</orcidid><orcidid>https://orcid.org/0000-0001-6380-2543</orcidid></search><sort><creationdate>20221101</creationdate><title>Reaction of 6-Oxocyclohexane-1,3-dicarboxamides with Binucleophilic Reagents. Antinociceptive Activity of the Synthesized Hydrazones and 2,3,4,5,6,7-Hexahydro-1H-indazoles</title><author>Gein, V. L. ; Lezhnina, D. D. ; Nosova, N. V. ; Makhmudov, R.R. ; Dmitriev, M. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-a336f8ba6370e2b8191ec05d9a7bb3ef2e26ed0d4a0d3776f5e4ca79ac006b053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Hydrazones</topic><topic>NMR spectroscopy</topic><topic>Organic Chemistry</topic><topic>Reagents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gein, V. L.</creatorcontrib><creatorcontrib>Lezhnina, D. D.</creatorcontrib><creatorcontrib>Nosova, N. V.</creatorcontrib><creatorcontrib>Makhmudov, R.R.</creatorcontrib><creatorcontrib>Dmitriev, M. V.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of organic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gein, V. L.</au><au>Lezhnina, D. D.</au><au>Nosova, N. V.</au><au>Makhmudov, R.R.</au><au>Dmitriev, M. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reaction of 6-Oxocyclohexane-1,3-dicarboxamides with Binucleophilic Reagents. Antinociceptive Activity of the Synthesized Hydrazones and 2,3,4,5,6,7-Hexahydro-1H-indazoles</atitle><jtitle>Russian journal of organic chemistry</jtitle><stitle>Russ J Org Chem</stitle><date>2022-11-01</date><risdate>2022</risdate><volume>58</volume><issue>11</issue><spage>1610</spage><epage>1616</epage><pages>1610-1616</pages><issn>1070-4280</issn><eissn>1608-3393</eissn><abstract>Novel hydrazones and hexahydro-1
H
-indazole-5-carboxamides were obtained via the reaction of 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides with tosylhydrazide, 2,4-dinitrophenylhydrazine, and phenylhydrazine, respectively. The structures of the products were proved by IR and
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C NMR spectroscopy, as well as X-ray diffraction analysis. The synthesized compounds were tested for antinociceptive activity.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070428022110070</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8512-0399</orcidid><orcidid>https://orcid.org/0000-0002-2326-3976</orcidid><orcidid>https://orcid.org/0000-0001-6380-2543</orcidid></addata></record> |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Chemistry Chemistry and Materials Science Hydrazones NMR spectroscopy Organic Chemistry Reagents |
| title | Reaction of 6-Oxocyclohexane-1,3-dicarboxamides with Binucleophilic Reagents. Antinociceptive Activity of the Synthesized Hydrazones and 2,3,4,5,6,7-Hexahydro-1H-indazoles |
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