Synthesis of a C3 Hydroxyproline-modified Carbapenem

Synthesis of a C3 Hydroxyproline-modified Carbapenem

Methyl (4 R )-4-hydroxy-1-(sulfanylacetyl)-l-prolinate was synthesized starting from trans -4-l-hydroxyprolinate methyl ester hydrochloride and then reacted with the known carbapenem enol phosphate to obtain the corresponding carbapenem and then to chemically more stable methyl ester.

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Veröffentlicht in:Russian journal of organic chemistry 2022-11, Vol.58 (11), p.1664-1667
Hauptverfasser: Valiullina, Z. R., Galeeva, A. M., Miftakhov, M. S.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Zusammenfassung:Methyl (4 R )-4-hydroxy-1-(sulfanylacetyl)-l-prolinate was synthesized starting from trans -4-l-hydroxyprolinate methyl ester hydrochloride and then reacted with the known carbapenem enol phosphate to obtain the corresponding carbapenem and then to chemically more stable methyl ester.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428022110173