Synthesis of Ethyl 3‐(1‐Acetyl‐3‐phenyl‐4,5‐dihydro‐1H‐pyrazol‐4‐yl)‐2,2‐difluoropropanoate from N‐Allyl‐N′‐benzylideneacetohydrazide and Ethyl 2‐Bromo‐2,2‐difluoroacetate

A route for cyclization reaction of N‐allyl‐N′‐benzylideneacetohydrazide and ethyl 2‐bromo‐2,2‐difluoroacetate to synthesize 3‐(1‐acetyl‐3‐phenyl‐4,5‐dihydro‐1H‐pyrazol‐4‐yl)‐2,2‐difluoropropanoate has been developed. This methodology features mild reaction conditions and good functional group toler...

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Veröffentlicht in:Advanced synthesis & catalysis 2022-12, Vol.364 (24), p.4300-4304
Hauptverfasser: Liu, Yi, Zhu, Wenjing, Yu, Xiao, Liu, Hongyan, Zhang, Zenghui, Zhang, Mei, Zhao, Jinbo, Wang, Yacong, Xia, Chengcai
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Sprache:eng
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Zusammenfassung:A route for cyclization reaction of N‐allyl‐N′‐benzylideneacetohydrazide and ethyl 2‐bromo‐2,2‐difluoroacetate to synthesize 3‐(1‐acetyl‐3‐phenyl‐4,5‐dihydro‐1H‐pyrazol‐4‐yl)‐2,2‐difluoropropanoate has been developed. This methodology features mild reaction conditions and good functional group tolerance, providing a direct approach for the preparation of dihydropyrazoles.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202201035