Synthesis of Ethyl 3‐(1‐Acetyl‐3‐phenyl‐4,5‐dihydro‐1H‐pyrazol‐4‐yl)‐2,2‐difluoropropanoate from N‐Allyl‐N′‐benzylideneacetohydrazide and Ethyl 2‐Bromo‐2,2‐difluoroacetate
A route for cyclization reaction of N‐allyl‐N′‐benzylideneacetohydrazide and ethyl 2‐bromo‐2,2‐difluoroacetate to synthesize 3‐(1‐acetyl‐3‐phenyl‐4,5‐dihydro‐1H‐pyrazol‐4‐yl)‐2,2‐difluoropropanoate has been developed. This methodology features mild reaction conditions and good functional group toler...
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Veröffentlicht in: | Advanced synthesis & catalysis 2022-12, Vol.364 (24), p.4300-4304 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A route for cyclization reaction of N‐allyl‐N′‐benzylideneacetohydrazide and ethyl 2‐bromo‐2,2‐difluoroacetate to synthesize 3‐(1‐acetyl‐3‐phenyl‐4,5‐dihydro‐1H‐pyrazol‐4‐yl)‐2,2‐difluoropropanoate has been developed. This methodology features mild reaction conditions and good functional group tolerance, providing a direct approach for the preparation of dihydropyrazoles. |
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ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.202201035 |