Noble Metal Polyacrylates: Cytotoxicity against Cisplatin- and Doxorubicin-Resistant Tumor Cells

Noble Metal Polyacrylates: Cytotoxicity against Cisplatin- and Doxorubicin-Resistant Tumor Cells

The cytotoxic activity of metal polyacrylates containing gold (aurumacryl) or silver (argacryl) has been studied in human breast cancer cell cultures sensitive (MCF-7) and resistant to cisplatin (MCF-7/CP) and doxorubicin (MCF-7/ADR) with parallel evaluation of the cytotoxicity of cisplatin and doxo...

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Veröffentlicht in:Biophysics (Oxford) 2022-10, Vol.67 (5), p.768-774
Hauptverfasser: Ostrovskaya, L. A., Korman, D. B., Nekrasova, E. I., Khochenkova, Yu. A., Bluhterova, N. V., Abzaeva, K. A.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and Medical Physics
Biophysics
Breast cancer
Cell Biophysics
Cell culture
Chemotherapy
Cisplatin
Cross-resistance
Cytotoxicity
Doxorubicin
Physics
Physics and Astronomy
Silver
Tumor cells
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Zusammenfassung:The cytotoxic activity of metal polyacrylates containing gold (aurumacryl) or silver (argacryl) has been studied in human breast cancer cell cultures sensitive (MCF-7) and resistant to cisplatin (MCF-7/CP) and doxorubicin (MCF-7/ADR) with parallel evaluation of the cytotoxicity of cisplatin and doxorubicin against these cell lines. Cells resistant to cisplatin and doxorubicin retain full sensitivity to the cytotoxic effects of aurumacryl and argacryl. The metal polyacrylates show no cross-resistance relationship with cisplatin or doxorubicin in the MCF-7 cell culture model.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350922050128