Renin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease
In this randomized trial, the discontinuation of renin–angiotensin system inhibitors in patients with advanced chronic kidney disease did not lead to a significant between-group difference in the long-term rate of decline in the eGFR.
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| Veröffentlicht in: | The New England journal of medicine 2022-12, Vol.387 (22), p.2021-2032 |
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| container_end_page | 2032 |
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| container_issue | 22 |
| container_start_page | 2021 |
| container_title | The New England journal of medicine |
| container_volume | 387 |
| creator | Bhandari, Sunil Mehta, Samir Khwaja, Arif Cleland, John G.F. Ives, Natalie Brettell, Elizabeth Chadburn, Marie Cockwell, Paul |
| description | In this randomized trial, the discontinuation of renin–angiotensin system inhibitors in patients with advanced chronic kidney disease did not lead to a significant between-group difference in the long-term rate of decline in the eGFR. |
| doi_str_mv | 10.1056/NEJMoa2210639 |
| format | Article |
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adverse effects</subject><subject>Angiotensin Receptor Antagonists - pharmacology</subject><subject>Angiotensin Receptor Antagonists - therapeutic use</subject><subject>Angiotensin-converting enzyme inhibitors</subject><subject>Angiotensin-Converting Enzyme Inhibitors - adverse effects</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Angiotensins - pharmacology</subject><subject>Antihypertensive Agents - adverse effects</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Antihypertensives</subject><subject>Blood pressure</subject><subject>Cardiology</subject><subject>Cardiology General</subject><subject>Clinical Medicine</subject><subject>Clinical Medicine General</subject><subject>Confidence intervals</subject><subject>Creatinine</subject><subject>Diabetes mellitus</subject><subject>End-stage renal disease</subject><subject>Epidermal growth factor receptors</subject><subject>Glomerular Filtration Rate</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypothesis testing</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - drug therapy</subject><subject>Kidney transplants</subject><subject>Medical research</subject><subject>Nephrology</subject><subject>Nephrology General</subject><subject>Patient safety</subject><subject>Patients</subject><subject>Proteins</subject><subject>Proteinuria</subject><subject>Quality of Life</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - drug therapy</subject><subject>Renin</subject><subject>Renin-Angiotensin System - drug effects</subject><subject>Statistical analysis</subject><subject>Variables</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVkM1OwzAQhC0EoqVw5IoiIY4Br38S-1iVQgsFJH7OVlI71BV2Spwg9cY78IY8CUYtB_awK60-zWgGoWPA54B5dnE_vrmrC0IAZ1TuoD5wSlPGcLaL-hgTkbJc0h46CGGJ4wCT-6hHM0oygLyPJo_GW__9-TX0r7ZujQ_WJ0_r0BqXTP3Clra1tU_ic6g_Cj83OhktmtrbeXJrtTfr5NIGUwRziPaq4i2Yo-0doJer8fNoks4erqej4Sx1IGWbloZJEIWpMOFx8wqEACJFiTXVgjBJBM6NFDmlFckzzWVMyQUAwZkAXdEBOt3orpr6vTOhVcu6a3y0VCRnlHMgQkTqZEt1pTNarRrrimat_oJH4GwDOBeUN0unAKvfQtW_QukPyjlkJw</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Bhandari, Sunil</creator><creator>Mehta, Samir</creator><creator>Khwaja, Arif</creator><creator>Cleland, John G.F.</creator><creator>Ives, Natalie</creator><creator>Brettell, Elizabeth</creator><creator>Chadburn, Marie</creator><creator>Cockwell, Paul</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-0996-9622</orcidid><orcidid>https://orcid.org/0000-0003-0635-6852</orcidid></search><sort><creationdate>20221201</creationdate><title>Renin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease</title><author>Bhandari, Sunil ; Mehta, Samir ; Khwaja, Arif ; Cleland, John G.F. ; Ives, Natalie ; Brettell, Elizabeth ; Chadburn, Marie ; Cockwell, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-m199t-be4918aef025aef5f1881298b0d3d82492807e98733f276d59105581120681df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiotensin Receptor Antagonists - adverse effects</topic><topic>Angiotensin Receptor Antagonists - pharmacology</topic><topic>Angiotensin Receptor Antagonists - therapeutic use</topic><topic>Angiotensin-converting enzyme inhibitors</topic><topic>Angiotensin-Converting Enzyme Inhibitors - adverse effects</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Angiotensins - pharmacology</topic><topic>Antihypertensive Agents - adverse effects</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Antihypertensives</topic><topic>Blood pressure</topic><topic>Cardiology</topic><topic>Cardiology General</topic><topic>Clinical Medicine</topic><topic>Clinical Medicine General</topic><topic>Confidence intervals</topic><topic>Creatinine</topic><topic>Diabetes mellitus</topic><topic>End-stage renal disease</topic><topic>Epidermal growth factor receptors</topic><topic>Glomerular Filtration Rate</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypothesis testing</topic><topic>Kidney diseases</topic><topic>Kidney Failure, Chronic - 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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2022-12, Vol.387 (22), p.2021-2032 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Angiotensin Receptor Antagonists - adverse effects Angiotensin Receptor Antagonists - pharmacology Angiotensin Receptor Antagonists - therapeutic use Angiotensin-converting enzyme inhibitors Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Angiotensins - pharmacology Antihypertensive Agents - adverse effects Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Antihypertensives Blood pressure Cardiology Cardiology General Clinical Medicine Clinical Medicine General Confidence intervals Creatinine Diabetes mellitus End-stage renal disease Epidermal growth factor receptors Glomerular Filtration Rate Hemodialysis Humans Hypertension Hypothesis testing Kidney diseases Kidney Failure, Chronic - complications Kidney Failure, Chronic - drug therapy Kidney transplants Medical research Nephrology Nephrology General Patient safety Patients Proteins Proteinuria Quality of Life Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - drug therapy Renin Renin-Angiotensin System - drug effects Statistical analysis Variables |
| title | Renin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease |
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