Renin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease

In this randomized trial, the discontinuation of renin–angiotensin system inhibitors in patients with advanced chronic kidney disease did not lead to a significant between-group difference in the long-term rate of decline in the eGFR.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2022-12, Vol.387 (22), p.2021-2032
Hauptverfasser:	Bhandari, Sunil, Mehta, Samir, Khwaja, Arif, Cleland, John G.F., Ives, Natalie, Brettell, Elizabeth, Chadburn, Marie, Cockwell, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Receptor Antagonists - adverse effects Angiotensin Receptor Antagonists - pharmacology Angiotensin Receptor Antagonists - therapeutic use Angiotensin-converting enzyme inhibitors Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Angiotensins - pharmacology Antihypertensive Agents - adverse effects Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Antihypertensives Blood pressure Cardiology Cardiology General Clinical Medicine Clinical Medicine General Confidence intervals Creatinine Diabetes mellitus End-stage renal disease Epidermal growth factor receptors Glomerular Filtration Rate Hemodialysis Humans Hypertension Hypothesis testing Kidney diseases Kidney Failure, Chronic - complications Kidney Failure, Chronic - drug therapy Kidney transplants Medical research Nephrology Nephrology General Patient safety Patients Proteins Proteinuria Quality of Life Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - drug therapy Renin Renin-Angiotensin System - drug effects Statistical analysis Variables
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Beschreibung
Zusammenfassung:	In this randomized trial, the discontinuation of renin–angiotensin system inhibitors in patients with advanced chronic kidney disease did not lead to a significant between-group difference in the long-term rate of decline in the eGFR.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2210639