Cytoprotective Effect of Biogenic Magnesium Hydroxide Nanoparticles Using Monodora myristica Aqueous Extract Against Oxidative Damage in Streptozotocin-Induced Diabetic Rats

In contemporary reports, biosynthesis of plant-mediated nanomaterials using different metals with enormous therapeutic evidences has been well documented in the management of human ailments with little or no records of the involvements of magnesium (Mg). This study therefore aimed at exploring the protective effects of phytomediated magnesium-based nanoparticles using Monodora myristica (M. myristica) seed (Mg(OH) 2 NP -Mm ) against oxidative damage in tissues of streptozotocin (STZ)-induced diabetic Wistar rats. Mg(OH) 2 NP -Mm was biosynthesized and characterized. Forty-eight adult male Wistar rats weighing 150–200 g were indiscriminately grouped into 8 groups of 6 rats each. Diabetes was induced with a low dose of STZ (55 mg/kg body weight; bw) and diabetic animals administered 50, 100, 150, and 200 mg/kg bw Mg(OH) 2 NP -Mm for 21 days, while control groups received glibenclamide (5 mg/kg bw) and Mg(OH) 2 -STD (150 mg/kg bw), respectively. However, treatment with Mg(OH) 2 NP -Mm caused a significant ( p