Evaluation of the revised ISTH overt DIC score (2018) for predicting 90‐day mortality in critically ill adult patients undergoing extracorporeal membrane oxygenation

Background and Objective Coagulopathy is a common and serious problem in patients who received extracorporeal membrane oxygenation (ECMO), and this study evaluated whether the 2018 diffuse intravascular coagulation (DIC) score established by the International Society on Thrombosis and Hemostasis (ISTH) is associated with 90‐day mortality in adult ECMO patients. Methods A retrospective study analyzed data from adult patients receiving ECMO in our hospital from September 2018 to April 2021. Pre‐ECMO DIC score and other variables were assessed and compared to predict 90‐day mortality. Results Among 103 eligible patients, 55.3% received V‐V ECMO and 44.7% received V‐A ECMO. The overall 90‐day mortality for study patients was 54.4%, including 45.6% in the V‐V group and 65.2% in the V‐A group. Multiple logistic regression analysis showed that after adjusting for sex, sepsis, and APACHE II score, pre‐ECMO DIC scores in the total and V‐V group predicted 90‐day mortality (odds ratio(OR): 1.419, 95% confidence interval (CI): 1.101–1.828; OR: 2.562; 95% CI: 1.452–4.520). Receiver operating characteristic (ROC) curves displayed that pre‐ECMO DIC score of 4 in the total and V‐V group was a good predictor of 90‐day mortality (area under the curve [AUC] = 0.706, 95% CI: 0.606–0.806; AUC = 0.737, 95% CI: 0.604–0.870). Kaplan–Meier curves demonstrated the 90‐day mortality of patients with pre‐ECMO DIC score ≥ 4 in the total and V‐V group was higher than that of patients with DIC score