Synthesis of Modified Acrylamide Copolymers with 2-Hydroxyethyl Methacrylate

Copolymers of acrylamide with 2-hydroxyethyl methacrylate were synthesized by radical heterophase copolymerization of monomers in 2-propanol initiated by AIBN as polymer reagents for subsequent modification containing 23.3–45.2 mol % of links (2-HEMA) with molecular weights of 20000–64000 Da. Acylation of the obtained copolymers with succinic anhydride in formamide in an inert atmosphere, which made it possible to obtain acrylamide terpolymers containing up to 26.5 mol% of carboxyl groups, was carried out. The following factors were determined: the temperature and duration of the reaction, the molar ratio of the reacting components, which made it possible to achieve a high 92–95% degree of acylation. On the basis of ternary carboxyl-containing acrylamide copolymers, non-toxic polymer complexes of amikacin containing 22.9 and 33.0 wt % of the antibiotic, which have a high prolonged anti-tuberculosis activity, were obtained.