Relation of serum soluble α-Klotho with hemodialysis, short-prospective study

Background: Klotho, is a protein associated with life extension plays central role in kidney disease progression, anti-aging, anti-oxidation, inflection of ion transport, and development of disturbed mineral metabolism. The aim of the study was to evaluate serum Soluble α-Klotho level (SAKL) in Chronic kidney disease (CKD) patients before and after dialysis in relation with kidney function variables. Methods: This short-prospective hospital-based study was done in the Department of Chemistry and Biochemistry, College of medicine, Tikrit University, Tikrit, Iraq. The study was carried out for 30 patients subjected to Hemodialysis (HD) recruited from Tikrit Teaching Hospital, hemodialysis unit from the period between 1st December, 2018 and 1st April,2019. The study also included 30 adult persons healthy with no prior medical or family history of CKD as a control participated in this study. The levels of SAKL and kidney function tests were estimated in the serum of 30 patients, before and after HD and compared with controls. Results: present study showed increased in the SAKL level in CKD patients before HD compared to healthy control group, and decreased in-group of CKD after HD compared to control group. Furthermore, there was a significant positive correlation between SAKL level and s. urea in CKD patients before HD and a positive correlation with creatinine clearance in patients after HD. Conclusion: There was a highly significant relation of SAKL with hemodialysis consequences.