Study of viscosity and thermodynamics a dual mixture of surfactants with tamoxifen at different temperatures

In view of the unique characteristics that distinguish the mixture of anionic and cationic surfactants from the properties of the components alone, a mixture (3 wt%) of both Sodium Dodecyle Sulphate (SDS) and Cetyl Trimethylammonium bromide (CTAB) as anionic and cationic surfactants was combined with tamoxifen, which is the drug belonging to the selective estrogen receptor degrader (SERD) actuators as a triple mixture, with the aim of making Tamoxifen has higher efficacy and fewer side effects, by using lower doses for both the drug, and the surface active substances in their single form. The results showed that the more viscous ratio of the two-mixture of the surface active substances was (50/50). The viscosity of the two mixture increased with increasing the concentration of the drug and thus it contains more micelles than in the lower concentrations of the parent concentration (3×10−5 M), where the higher value was (0.43578 Pa.s×102) at a temperature of 293.65K and the lower value was (0.08708 Pa s×102) at 310.65K. The two mixtures (bilateral and triple) were diagnosed using both the scanning electron microscope (SEM), the transmission electron microscope (TEM), and the X-ray diffraction (XRD). The presence of the mixture of surface active substances led to the spread of tamoxifen particles rather than their clumping, which gives better possibility of treating the disease in addition to its appearance in the nanoscale and in the form of clear filaments due to the molecular interference that led to the growth of micelles due to increased viscosity.