Early Amino Acids in Extremely Preterm Infants and Neurodisability at 2 Years

In a randomized, controlled trial involving infants with extremely low birth weight, parenteral amino acids at a dose of 1 g per day for 5 days after birth did not increase neurodisability-free survival at 2 years.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2022-11, Vol.387 (18), p.1661-1672
Hauptverfasser:	Bloomfield, Frank H., Jiang, Yannan, Harding, Jane E., Crowther, Caroline A., Cormack, Barbara E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - administration & dosage Amino Acids - adverse effects Amino Acids - therapeutic use Antibiotics Australia Birth weight Brain research Catheters Child, Preschool Children Clinical trials Complications of Pregnancy Congenital diseases Consent Coronary vessels Design Diet Disability Double-Blind Method Ductus Arteriosus, Patent - etiology Ethics Executive function Gastroenterology Gestational age Growth and Development Gynecology Humans Infant Infant, Extremely Low Birth Weight Infant, Extremely Premature Infant, Newborn Infants Intensive care Intensive care units Intensive Care, Neonatal Low birth weight Multiple births Neonatal care Neonates Neonatology Nervous System Diseases - diagnosis Nervous System Diseases - etiology Nervous System Diseases - prevention & control Neurodevelopmental Disorders - diagnosis Neurodevelopmental Disorders - etiology Neurodevelopmental Disorders - prevention & control Neurology Neurosurgery Neurosurgery General Newborn babies Nutrition Nutrition (Pediatrics) Obstetrics Parenteral nutrition Parenteral Nutrition - methods Pediatrics Placebos Pregnancy Premature babies Proteins Survival
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Beschreibung
Zusammenfassung:	In a randomized, controlled trial involving infants with extremely low birth weight, parenteral amino acids at a dose of 1 g per day for 5 days after birth did not increase neurodisability-free survival at 2 years.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2204886