S100A14 protein as diagnostic and prognostic marker in hepatocellular carcinoma

Background Protein S100A14 has recently been implicated in the progress of several types of cancers. This study aimed to investigate the clinical significance of S100A14 in the diagnosis of hepatocellular carcinoma (HCC). Results S100A14 was significantly elevated in the HCC group. A cut-off value f...

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Veröffentlicht in:	Egyptian Liver Journal 2019-12, Vol.9 (1), p.9-6, Article 9
Hauptverfasser:	Mohamed, Basma Fathy, Serag, Waleed Mohamed, Abdelal, Reda Mahamoud, Elsergany, Heba Fadl
Format:	Artikel
Sprache:	eng
Schlagworte:	Cirrhosis College teachers Hepatitis C Hepatocellular carcinoma Hepatology Hepatoma Immunoassay Liver cancer Liver cirrhosis Medicine Medicine & Public Health Original Research Article Proteins Research centers S100A14 Signal transduction Tumorigenesis Tumors Variance analysis
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Zusammenfassung:	Background Protein S100A14 has recently been implicated in the progress of several types of cancers. This study aimed to investigate the clinical significance of S100A14 in the diagnosis of hepatocellular carcinoma (HCC). Results S100A14 was significantly elevated in the HCC group. A cut-off value for serum S100A14 between the HCC group and cirrhosis group is > 0.47 with a sensitivity of 100% and specificity of 88.57%. S100A14 level was a significant diagnostic factor for HCC and a good reference for HCC progression. Conclusion These results suggest that S100A14 is a good diagnostic marker for HCC.
ISSN:	2090-6226 2090-6218 2090-6226
DOI:	10.1186/s43066-019-0015-6