Assessment of soluble receptor for advance glycation end product level in patients suffering from sickle cell anemia related with nephropathy

Inherited hemolytic anemia represented by sickle cell disesae characterized by subsituition of valine for glutamic and causing adjusment of hemoglobin (Hb) quality also it was realized that Hb molecule subsituation of the β-globin chain at six circumstance caused to transfer of normal adult hemoglobin (HbA), to sickle hemoglobin (HbS). Current study was design to evaluate avery important markers for prediction or as prognostic to sickle cell anemia disease represented by Receptor for Advance of Glycation End Product (RAGE). Methods: The study was carried out in Al–Najaf province in Al-Zahraa TeachingHospital espically by cross-sectional study investigation at duration time from first July to tirty of November, 2019. This investigation was included fifty-five (suffering from sickle cell disease at age from 3-49 years, also appearantly healthy group as number was thirty. Evaluation of all critria were done by using Elisa technique for (RAGE) level and creatinine concentration and made a relatiom between both RAGE and creatinine with some of critria such as gender, body mass index, duration of disease and age .Results: Decrement was indicated significantly (P-Value