Ligand-controlled regiodivergent direct arylation of indoles via oxidative boron Heck reaction

Ligand-controlled regiodivergent direct arylation of indoles via oxidative boron Heck reaction

Ligand-controlled direct arylation of indoles via Pd( ii ) catalyzed oxidative boron Heck reaction under aerobic conditions is reported. This methodology provides a regiodivergent route for C2 or C3 aryl indoles in a protection free and acid/base free manner.

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Veröffentlicht in:Organic Chemistry Frontiers 2022-10, Vol.9 (21), p.5906-5911
Hauptverfasser: Yang, Yo-Sep, Lee, Sangmin, Son, Seung Hwan, Yoo, Hyung-Seok, Jang, Yoon Hu, Shin, Jeong-Won, Won, Hyuck-Jae, Sim, Jaehoon, Kim, Nam-Jung
Format: Artikel
Sprache:eng
Schlagworte:
Aerobic conditions
Boron
Indoles
Ligands
Organic chemistry
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Zusammenfassung:Ligand-controlled direct arylation of indoles via Pd( ii ) catalyzed oxidative boron Heck reaction under aerobic conditions is reported. This methodology provides a regiodivergent route for C2 or C3 aryl indoles in a protection free and acid/base free manner.
ISSN:2052-4129
2052-4110
2052-4129
2052-4110
DOI:10.1039/D2QO01326F