Effects of an enzyme agent containing mutanase and dextranase for treatment of biofilms in bacteria- and yeast-infected canine otitis externa

Effects of an enzyme agent containing mutanase and dextranase for treatment of biofilms in bacteria- and yeast-infected canine otitis externa

The purpose of this study was to evaluate in detail both the in vivo and in vitro efficacy of the enzyme agents, ZYMOX® Plus Otic (ZYMOX-P), in the treatment of canine otitis externa (OE). Eight dogs with a diagnosis of non-seasonal severe chronic OE were recruited for the study. ZYMOX-P was adminis...

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Veröffentlicht in:Polish journal of veterinary sciences 2022-01, Vol.25 (3), p.383-389
1. Verfasser: Fujimura, M.
Format: Artikel
Sprache:eng
Schlagworte:
Antimicrobial agents
Bacteria
Biofilms
Colonies
Dermatitis
Dextranase
Dogs
Drug dosages
Drug resistance
Edema
Enzymes
Erythema
Exopolysaccharides
Infections
Laboratories
Otitis
Otitis externa
Pathogens
Pruritus
Statistical analysis
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Zusammenfassung:The purpose of this study was to evaluate in detail both the in vivo and in vitro efficacy of the enzyme agents, ZYMOX® Plus Otic (ZYMOX-P), in the treatment of canine otitis externa (OE). Eight dogs with a diagnosis of non-seasonal severe chronic OE were recruited for the study. ZYMOX-P was administered for 2-4 weeks. The Otitis Index Score (OTIS3) and bacteria or yeast colony growth were measured. Also, minimum biofilm (BF) formation inhibition concentration (MBIC) and BF bactericidal concentration (BBC) were measured in vitro. OTIS3 showed a statistically significant reduction after treatment (88.2%, p
ISSN:1505-1773
2300-2557
DOI:10.24425/pjvs.2022.142021