Outcomes and management of pregnancy in women with bleeding disorder of unknown cause

Background Patients with a bleeding tendency with normal laboratory tests have been described as having an unclassified bleeding disorder or bleeding disorder of unknown cause (BDUC). There are very little data available on how to manage pregnancy. Objectives To study management and outcomes of these patients at four United Kingdom hemophilia comprehensive care centers. Methods Retrospective case note review from 2010–2020. Results Sixty deliveries in 36 patients were recorded. The median International Society on Thrombosis and Haemostasis bleeding assessment tool score was 9. In 54 cases for which data were available, the odds ratio for post partum hemorrhage (PPH) was 6.3 for no primary hemostatic prophylaxis versus prophylaxis (95% confidence interval 1.2–34.2, p