New Antimicrobial Polymeric Microspheres Containing Azomethine

Herein, new polymeric microspheres containing azomethine (PS–OPA, PS–OPA–Pt, PS–OPA–Ni, PS–OPA–Mn and PS–OPA–Cu) were synthesized and investigated by elemental analysis, FT-IR, SEM–EDX, TGA–DTA, UV–Vis, GPC and magnetic susceptibility. Antibacterial and antifungal activities of the synthesized polymeric microspheres were evaluated against pathogenic bacteria ( Staphylococcus epidermidis ATCC12228 , Bacillus cereus RSKK863 , Staphylococcus aureus ATCC25923 , Enterobacter aerogenes, Pseudomonas aeroginosa sp. , Klebsiella pneumonia ATCC27853 , Salmonella type H NCTC9018394 , Proteus vulgaris RSKK96026 , Escherichia coli ATCC1280) and yeast ( Candida albicans Y-1200-NIH) by the well-diffusion method for potential biomedical applications. It was determined that polymeric microspheres exhibited higher inhibition effect against B. cereus , E. aerogenes , P. aeruginosa , P. vulgaris and showed higher antifungal activity than standard nystatin. Graphical Abstract