Nickel()-catalyzed highly selective 1,2-diborylation of non-activated monosubstituted alkenes

Nickel()-catalyzed highly selective 1,2-diborylation of non-activated monosubstituted alkenes

A practical method for 1,2-diborylation of non-activated monosubstituted alkenes via nickel catalysis has been developed. The protocol features high functional group tolerance and can be applied for the formal synthesis of drugs and modification of natural product derivatives. Preliminary mechanisti...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-10, Vol.58 (83), p.1179-11712
Hauptverfasser: Zhang, Zhi-Kai, Feng, Ya-Li, Ruan, Zheng, Xu, Yuan-Qing, Cao, Zhong-Yan, Li, Meng-Hua, Wang, Chao
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes
Catalysis
Functional groups
Natural products
Nickel
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Zusammenfassung:A practical method for 1,2-diborylation of non-activated monosubstituted alkenes via nickel catalysis has been developed. The protocol features high functional group tolerance and can be applied for the formal synthesis of drugs and modification of natural product derivatives. Preliminary mechanistic studies imply the involvement of a Ni( ii ) catalytic cycle. A practical method for 1,2-diborylation of non-activated monosubstituted alkenes via nickel catalysis has been developed.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc04382c