Novel Copper Tagged Supported Ionic Liquid Phase Catalyst for the Synthesis of 1,4‑Disubstituted 1,2,3‑Triazoles via Cu-catalyzed Azide–Alkyne Cycloaddition Reactions in Water

The present manuscript explored the design, synthesis and applications of novel ascorbate functionalized copper tagged polymer-supported ionic liquid phase catalyst (PSILPC). A newly synthesized SILP catalyst was characterized by various physicochemical techniques such as FT-IR, XRD, SEM, TEM, EDS, XPS and ICP-AES. The catalytic performance of the synthesized SILP catalyst was investigated for copper-catalyzed azide-alkyne cycloaddition (CuAAC) of alkyl or aryl halide, sodium azide and terminal alkyne provides a series of 1,4-disubstituted-1,2,3-triazoles in excellent yields. This protocol depicted the advantages such as the use of water as an eco-benign solvent, in situ generations of azides from aryl/alkyl halides, excellent yields, mild reaction conditions, simple workup, shorter reaction time, high turnover number and high turnover frequency. Moreover, robust, thermally stable and highly efficient SILP catalyst could be effortlessly recovered and reused seven times without significant loss of its catalytic activity makes the present protocol more fascinating from an economic and environmental perspective. Graphical Abstract