P19 Factors associated with HCC stage at presentation and survival in a UK population

Background and AimsRisk factors for hepatocellular carcinoma (HCC) include cirrhosis and diabetes, but patient- and disease-related factors in prognosis have not been widely explored. Evidence highlights ethnic disparity in HCC stage at presentation and survival in the USA, but there is little evidence evaluating any disparity in the UK.We sought to evaluate the factors associated with HCC stage at presentation and survival in a UK population.MethodWe retrospectively analysed data from referrals to HCC multidisciplinary teams in 4 regional centres: East London and Essex, Nottingham, Coventry, and Bristol, between 2007 to 2021. Early-stage at presentation was defined as Barcelona Clinic Liver Centre (BCLC) Stages 0 and A, late-stage was defined as BCLC Stages C and D. Analyses were conducted using Cox regression models for survival and logistic regression models for stage at presentation, all adjusted for age, sex, aetiology of liver disease, HCC surveillance and centre.ResultsWe included 1357 patients with a median follow-up of 12 months. 31% of patients had Non-Alcoholic Fatty Liver Disease (NAFLD), 33% had Viral hepatitis, and 18% had Alcoholic Liver Disease (ALD).The overall 2-year survival rate was 40%. White ethnicity was independently associated with reduced mortality (Hazard ratio [HR] 0.835, p=0.043), but not early-stage presentation (Odds ratio [OR] 1.324, p=0.089).21% of patients had non-cirrhotic HCC. Patients with NAFLD were more likely to develop non-cirrhotic HCC compared with patients with Viral hepatitis and ALD (24% vs. 10%, p