Screening of Medicinal Compounds in Blood by Atmospheric Pressure Laser Plasma Ionization Mass Spectrometry
We proposed a procedure for screening drug compounds by high-resolution mass spectrometry with atmospheric pressure laser plasma ionization (APLPI). The analytical performance of the method was studied on examples of five medicinal compounds: Lidocaine, Bendazole, Papaverine, Chloropyramine, and Car...
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| Veröffentlicht in: | Journal of analytical chemistry (New York, N.Y.) N.Y.), 2022-10, Vol.77 (10), p.1307-1314 |
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| container_title | Journal of analytical chemistry (New York, N.Y.) |
| container_volume | 77 |
| creator | Kravets, K. Yu Timakova, S. I. Grechnikov, A. A. Borodkov, A. S. Laptinskaya, P. K. Kuzmin, V. S. Simanovsky, Ya. O. |
| description | We proposed a procedure for screening drug compounds by high-resolution mass spectrometry with atmospheric pressure laser plasma ionization (APLPI). The analytical performance of the method was studied on examples of five medicinal compounds: Lidocaine, Bendazole, Papaverine, Chloropyramine, and Carbamazepine. Calibration dependences were obtained in the analysis of model solutions and blood samples; sensitivity coefficients were determined. The relative standard deviation of the results is in the range 20–27%. The APLPI technique can detect promptly and reliably the studied medicinal compounds at concentrations 0.5–6 ng/mL in a sample. The sensitivity of APLPI exceeds that of atmospheric pressure electrospray ionization by 4–16 times. |
| doi_str_mv | 10.1134/S1061934822100082 |
| format | Article |
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The APLPI technique can detect promptly and reliably the studied medicinal compounds at concentrations 0.5–6 ng/mL in a sample. 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O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Screening of Medicinal Compounds in Blood by Atmospheric Pressure Laser Plasma Ionization Mass Spectrometry</atitle><jtitle>Journal of analytical chemistry (New York, N.Y.)</jtitle><stitle>J Anal Chem</stitle><date>2022-10-01</date><risdate>2022</risdate><volume>77</volume><issue>10</issue><spage>1307</spage><epage>1314</epage><pages>1307-1314</pages><issn>1061-9348</issn><eissn>1608-3199</eissn><abstract>We proposed a procedure for screening drug compounds by high-resolution mass spectrometry with atmospheric pressure laser plasma ionization (APLPI). The analytical performance of the method was studied on examples of five medicinal compounds: Lidocaine, Bendazole, Papaverine, Chloropyramine, and Carbamazepine. Calibration dependences were obtained in the analysis of model solutions and blood samples; sensitivity coefficients were determined. The relative standard deviation of the results is in the range 20–27%. The APLPI technique can detect promptly and reliably the studied medicinal compounds at concentrations 0.5–6 ng/mL in a sample. The sensitivity of APLPI exceeds that of atmospheric pressure electrospray ionization by 4–16 times.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1061934822100082</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Analytical Chemistry Atmospheric pressure Blood Carbamazepine Chemistry Chemistry and Materials Science Ionization Laser plasmas Laser-plasma interactions Lidocaine Mass spectrometry Methods Papaverine Screening Spectroscopy |
| title | Screening of Medicinal Compounds in Blood by Atmospheric Pressure Laser Plasma Ionization Mass Spectrometry |
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