Screening of Medicinal Compounds in Blood by Atmospheric Pressure Laser Plasma Ionization Mass Spectrometry

We proposed a procedure for screening drug compounds by high-resolution mass spectrometry with atmospheric pressure laser plasma ionization (APLPI). The analytical performance of the method was studied on examples of five medicinal compounds: Lidocaine, Bendazole, Papaverine, Chloropyramine, and Carbamazepine. Calibration dependences were obtained in the analysis of model solutions and blood samples; sensitivity coefficients were determined. The relative standard deviation of the results is in the range 20–27%. The APLPI technique can detect promptly and reliably the studied medicinal compounds at concentrations 0.5–6 ng/mL in a sample. The sensitivity of APLPI exceeds that of atmospheric pressure electrospray ionization by 4–16 times.