In Situ Silver‐Based Electrochemical Oncolytic Bioreactor (Adv. Mater. 40/2022)

Bioreactors In article number 2109973, Liping Zhong, Kun Zhang, Yongxiang Zhao, and co‐workers describe how a tumor‐microenvironment‐enabled in situ silver‐based electrochemical oncolytic bioreactor (SEOB) unlocks antitumor Ag+ prodrugs for highly efficient subcutaneous and orthotopic tumor recessio...

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Veröffentlicht in:	Advanced materials (Weinheim) 2022-10, Vol.34 (40), p.n/a
Hauptverfasser:	Huang, Yong, Zhong, Liping, Li, Xiaotong, Wu, Pan, He, Jian, Tang, Chao, Tang, Zhiping, Su, Jing, Feng, Zhenbo, Wang, Bing, Ma, Yun, Peng, Hongmei, Bai, Zhihao, Zhong, Yi, Liang, Ying, Lu, Wenxi, Luo, Ruiyu, Li, Jinghua, Li, Haiping, Deng, Zhiming, Lan, Xianli, Liu, Ziqun, Zhang, Kun, Zhao, Yongxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	5,5′,6,6′‐tetrachloro‐1,1,3,3′‐tetraethylbenzimidazolyl carbocyanine iodide aptamer targeting Bioreactors Graphene Hydrogen peroxide intratumoral silver‐based nanosynthetic prodrugs Materials science Nanoparticles primate biosafety Reducing agents Silver silver‐based electrochemical oncolytic bioreactors
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Zusammenfassung:	Bioreactors In article number 2109973, Liping Zhong, Kun Zhang, Yongxiang Zhao, and co‐workers describe how a tumor‐microenvironment‐enabled in situ silver‐based electrochemical oncolytic bioreactor (SEOB) unlocks antitumor Ag+ prodrugs for highly efficient subcutaneous and orthotopic tumor recession via activating production of reactive oxygen species (ROS). Reduced graphene oxide (rGO), featuring 20‐fold larger catalysis rate than GO, allows intratumoral H2O2 as reductants to reduce Ag+ into silver nanoparticles especially after uniting with vitamin‐C‐mediated H2O2 production.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.202270280