Endosomal recycling defects link Huntington' s disease with McLeod syndrome

Endosomal recycling defects link Huntington' s disease with McLeod syndrome

Chhetri and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to the cell surface and significantly reduces mangane...

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Veröffentlicht in:The Journal of cell biology 2022-10, Vol.221 (10), p.1
Hauptverfasser: Marsan, Elise, Huang, Eric J
Format: Artikel
Sprache:eng
Schlagworte:
Cell membranes
Cell surface
Huntingtin
Manganese
McLeod syndrome
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Zusammenfassung:Chhetri and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to the cell surface and significantly reduces manganese transport across cell membrane.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.202208164