Current use and potential role of radioguided surgery in brain tumours

Purpose The aim of this mini-review is to discuss the possible role of radioguided surgery in brain tumours and, in particular, in gliomas. Methods A research in the PubMed/Medline database was carried out to identify relevant studies evaluating radioguided surgery in brain tumours. Results Radioguided surgery results using gamma (γ)-emitting tracers and γ-detection probes were summarised. Most importantly, the review included preliminary findings with novel approaches, particularly those relying on the use of beta (β) − emitting isotopes and a dedicated β probe. Conclusion Although few data are available in the current literature, the use of β probes could be useful to accurately identify surgical margins in brain tumours. Nevertheless, further in vivo studies are required.