Trypsin‐chymotrypsin as an adjuvant to diclofenac potassium on the postoperative sequelae following mandibular third molar impactions—A comparative study

Objectives To assess the efficacy of Chymotrypsin‐trypsin with Diclofenac versus Diclofenac alone on the postoperative sequelae of lower third molar disimpactions. Methods A total of 60 patients to undergo lower third molar surgery were divided randomly into 2 equal groups. Group 1 (30 patients) received Chymotrypsin‐trypsin with Diclofenac tablets and conventional treatment whilst Group 2 (30 patients) received Diclofenac Potassium 50 mg and conventional treatment. Pain, facial swelling, and Interincisal opening were measured for each patient on the 1st, 3rd and 7th days postoperatively. Results In GROUP 1, the mean reduction of VAS Score for postoperative pain was 4.33 to 0.76, whereas GROUP 2 reported a decrease in score from 3.06 to 0.93. During the time period of Day 1 to Day 7, GROUP 1 reported a mean reduction of swelling score to 0.26 on Day 7, whilst GROUP 2 reported a swelling score of 0.80 on Day 7. For the Interincisal Opening and Trismus, GROUP 1 had mean scores from 0.40 (Day 1) to 1.10 (Day 3) and 0.26 on Day 7, whilst GROUP 2 had mean scores from 0.63 (Day 1) to 1.20 (day 3) and 0.73 at Day 7. GROUP 1 reported no Adverse symptoms, whereas GROUP 2 showed symptoms on Day 1 and Day 3. Conclusion Trypsin‐Chymotrypsin in combination with Diclofenac is an effective and superior analgesic when compared to Diclofenac alone in the treatment of postoperative sequelae of lower third molar surgery with good anti‐inflammatory activity.