Rearranged Dichapetalin‐Type Triterpenoids with Cytotoxic Activity from Dichapetalum gelonioides
Comprehensive Summary Dichagelinoids A—C (1—3), three unusual dichapetalin‐type triterpenoids, together with two biogenetically related derivatives dichagelinoids D and E (4 and 5) were isolated and characterized by solid data from Dichapetalum gelonioides. Compounds 1—3 possess a common rearranged...
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| Veröffentlicht in: | Chinese journal of chemistry 2022-11, Vol.40 (21), p.2531-2538 |
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| container_issue | 21 |
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| container_title | Chinese journal of chemistry |
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| creator | Gao, Xin‐Hua Wang, Xi‐Yuan Zhou, Jun‐Su Zhang, Yan Liu, Hong‐Chun Zhou, Bin Yue, Jian‐Min |
| description | Comprehensive Summary
Dichagelinoids A—C (1—3), three unusual dichapetalin‐type triterpenoids, together with two biogenetically related derivatives dichagelinoids D and E (4 and 5) were isolated and characterized by solid data from Dichapetalum gelonioides. Compounds 1—3 possess a common rearranged C ring and different C6—C2 modified motifs at the A rings. Biological evaluation revealed that compounds 1—3 showed distinct cytotoxic activity against the tested human cancer cell lines.
Five dichapetalin‐type triterpenoids, dichagelinoids A—E (1—5), were isolated and characterized from Dichapetalum gelonioides. Compounds 1—3 featuring a common rearranged C ring and different C6—C2 modified motifs at the A rings, were verified as potent cytotoxic agents. |
| doi_str_mv | 10.1002/cjoc.202200383 |
| format | Article |
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Dichagelinoids A—C (1—3), three unusual dichapetalin‐type triterpenoids, together with two biogenetically related derivatives dichagelinoids D and E (4 and 5) were isolated and characterized by solid data from Dichapetalum gelonioides. Compounds 1—3 possess a common rearranged C ring and different C6—C2 modified motifs at the A rings. Biological evaluation revealed that compounds 1—3 showed distinct cytotoxic activity against the tested human cancer cell lines.
Five dichapetalin‐type triterpenoids, dichagelinoids A—E (1—5), were isolated and characterized from Dichapetalum gelonioides. Compounds 1—3 featuring a common rearranged C ring and different C6—C2 modified motifs at the A rings, were verified as potent cytotoxic agents.</description><identifier>ISSN: 1001-604X</identifier><identifier>EISSN: 1614-7065</identifier><identifier>DOI: 10.1002/cjoc.202200383</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH & Co. KGaA</publisher><subject>Cytotoxic activity ; Cytotoxicity ; Dichapetalin‐type triterpenoids ; Dichapetalum gelonioides ; Natural products ; Structural elucidation ; Triterpenoids ; Tumor cell lines</subject><ispartof>Chinese journal of chemistry, 2022-11, Vol.40 (21), p.2531-2538</ispartof><rights>2022 SIOC, CAS, Shanghai, & WILEY‐VCH GmbH.</rights><rights>2022 SIOC, CAS, Shanghai, & WILEY‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3173-25ef694b714084447364c75f32af6a2019cd2195999aac57e44ab0cb7850a2743</citedby><cites>FETCH-LOGICAL-c3173-25ef694b714084447364c75f32af6a2019cd2195999aac57e44ab0cb7850a2743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcjoc.202200383$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcjoc.202200383$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Gao, Xin‐Hua</creatorcontrib><creatorcontrib>Wang, Xi‐Yuan</creatorcontrib><creatorcontrib>Zhou, Jun‐Su</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Liu, Hong‐Chun</creatorcontrib><creatorcontrib>Zhou, Bin</creatorcontrib><creatorcontrib>Yue, Jian‐Min</creatorcontrib><title>Rearranged Dichapetalin‐Type Triterpenoids with Cytotoxic Activity from Dichapetalum gelonioides</title><title>Chinese journal of chemistry</title><description>Comprehensive Summary
Dichagelinoids A—C (1—3), three unusual dichapetalin‐type triterpenoids, together with two biogenetically related derivatives dichagelinoids D and E (4 and 5) were isolated and characterized by solid data from Dichapetalum gelonioides. Compounds 1—3 possess a common rearranged C ring and different C6—C2 modified motifs at the A rings. Biological evaluation revealed that compounds 1—3 showed distinct cytotoxic activity against the tested human cancer cell lines.
Five dichapetalin‐type triterpenoids, dichagelinoids A—E (1—5), were isolated and characterized from Dichapetalum gelonioides. Compounds 1—3 featuring a common rearranged C ring and different C6—C2 modified motifs at the A rings, were verified as potent cytotoxic agents.</description><subject>Cytotoxic activity</subject><subject>Cytotoxicity</subject><subject>Dichapetalin‐type triterpenoids</subject><subject>Dichapetalum gelonioides</subject><subject>Natural products</subject><subject>Structural elucidation</subject><subject>Triterpenoids</subject><subject>Tumor cell lines</subject><issn>1001-604X</issn><issn>1614-7065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkMtKAzEUQIMoWKtb1wOup-adZlnGN4WCVHAXMmmmTWknY5JaZ-cn-I1-iVMq6s7VvYtz7oUDwDmCAwQhvjRLbwYYYgwhGZID0EMc0VxAzg67HUKUc0ifj8FJjMuOFwLzHigfrQ5B13M7y66cWejGJr1y9ef7x7RtbDYNLtnQ2Nq7Wcy2Li2yok0--TdnspFJ7tWlNquCX__RN-tsble-dp1k4yk4qvQq2rPv2QdPN9fT4i4fT27vi9E4NwQJkmNmKy5pKRCFQ0qpIJwawSqCdcU1hkiaGUaSSSm1NkxYSnUJTSmGDGosKOmDi_3dJviXjY1JLf0m1N1LhQWSnAmGSEcN9pQJPsZgK9UEt9ahVQiqXUe166h-OnaC3Atbt7LtP7QqHibFr_sFFlB4sQ</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Gao, Xin‐Hua</creator><creator>Wang, Xi‐Yuan</creator><creator>Zhou, Jun‐Su</creator><creator>Zhang, Yan</creator><creator>Liu, Hong‐Chun</creator><creator>Zhou, Bin</creator><creator>Yue, Jian‐Min</creator><general>WILEY‐VCH Verlag GmbH & Co. KGaA</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20221101</creationdate><title>Rearranged Dichapetalin‐Type Triterpenoids with Cytotoxic Activity from Dichapetalum gelonioides</title><author>Gao, Xin‐Hua ; Wang, Xi‐Yuan ; Zhou, Jun‐Su ; Zhang, Yan ; Liu, Hong‐Chun ; Zhou, Bin ; Yue, Jian‐Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3173-25ef694b714084447364c75f32af6a2019cd2195999aac57e44ab0cb7850a2743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cytotoxic activity</topic><topic>Cytotoxicity</topic><topic>Dichapetalin‐type triterpenoids</topic><topic>Dichapetalum gelonioides</topic><topic>Natural products</topic><topic>Structural elucidation</topic><topic>Triterpenoids</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Xin‐Hua</creatorcontrib><creatorcontrib>Wang, Xi‐Yuan</creatorcontrib><creatorcontrib>Zhou, Jun‐Su</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Liu, Hong‐Chun</creatorcontrib><creatorcontrib>Zhou, Bin</creatorcontrib><creatorcontrib>Yue, Jian‐Min</creatorcontrib><collection>CrossRef</collection><jtitle>Chinese journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Xin‐Hua</au><au>Wang, Xi‐Yuan</au><au>Zhou, Jun‐Su</au><au>Zhang, Yan</au><au>Liu, Hong‐Chun</au><au>Zhou, Bin</au><au>Yue, Jian‐Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rearranged Dichapetalin‐Type Triterpenoids with Cytotoxic Activity from Dichapetalum gelonioides</atitle><jtitle>Chinese journal of chemistry</jtitle><date>2022-11-01</date><risdate>2022</risdate><volume>40</volume><issue>21</issue><spage>2531</spage><epage>2538</epage><pages>2531-2538</pages><issn>1001-604X</issn><eissn>1614-7065</eissn><abstract>Comprehensive Summary
Dichagelinoids A—C (1—3), three unusual dichapetalin‐type triterpenoids, together with two biogenetically related derivatives dichagelinoids D and E (4 and 5) were isolated and characterized by solid data from Dichapetalum gelonioides. Compounds 1—3 possess a common rearranged C ring and different C6—C2 modified motifs at the A rings. Biological evaluation revealed that compounds 1—3 showed distinct cytotoxic activity against the tested human cancer cell lines.
Five dichapetalin‐type triterpenoids, dichagelinoids A—E (1—5), were isolated and characterized from Dichapetalum gelonioides. Compounds 1—3 featuring a common rearranged C ring and different C6—C2 modified motifs at the A rings, were verified as potent cytotoxic agents.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH & Co. KGaA</pub><doi>10.1002/cjoc.202200383</doi><tpages>1</tpages></addata></record> |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Cytotoxic activity Cytotoxicity Dichapetalin‐type triterpenoids Dichapetalum gelonioides Natural products Structural elucidation Triterpenoids Tumor cell lines |
| title | Rearranged Dichapetalin‐Type Triterpenoids with Cytotoxic Activity from Dichapetalum gelonioides |
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