Synthesis and evaluation of cytotoxicity of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines
A general and efficient method for the synthesis of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines via cyclocondensation of aryl(benzyl)sulfanylacetic and -propionic acids with thiosemicarbazide upon their heating in POCl 3 was developed. Both aryl- and benzylsulfanilacetic and -pro...
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| Veröffentlicht in: | Russian chemical bulletin 2022-08, Vol.71 (8), p.1801-1805 |
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| container_title | Russian chemical bulletin |
| container_volume | 71 |
| creator | Serkov, S. A. Sigai, N. V. Kostikova, N. N. Fedorov, A. E. Gazieva, G. A. |
| description | A general and efficient method for the synthesis of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines
via
cyclocondensation of aryl(benzyl)sulfanylacetic and -propionic acids with thiosemicarbazide upon their heating in POCl
3
was developed. Both aryl- and benzylsulfanilacetic and -propionic acids were successfully involved in this reaction to give the target thidiazolamines in high yields (63–98%). |
| doi_str_mv | 10.1007/s11172-022-3592-1 |
| format | Article |
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via
cyclocondensation of aryl(benzyl)sulfanylacetic and -propionic acids with thiosemicarbazide upon their heating in POCl
3
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via
cyclocondensation of aryl(benzyl)sulfanylacetic and -propionic acids with thiosemicarbazide upon their heating in POCl
3
was developed. Both aryl- and benzylsulfanilacetic and -propionic acids were successfully involved in this reaction to give the target thidiazolamines in high yields (63–98%).</description><subject>Amines</subject><subject>Aromatic compounds</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Full Articles</subject><subject>Inorganic Chemistry</subject><subject>Organic Chemistry</subject><subject>Propionic acid</subject><subject>Substitutes</subject><subject>Synthesis</subject><subject>Toxicity</subject><issn>1066-5285</issn><issn>1573-9171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LxDAQxYMouK5-AG8FLwobzSRpkz3K4j8QPKyewzRN3azddm1SsX56u1bw5GVmHrz3Bn6EnAK7BMbUVQAAxSnjnIp0zinskQmkStA5KNgfbpZlNOU6PSRHIawZY1xrPSFvy76OKxd8SLAuEveBVYfRN3XSlIntYxObT2997Hd6SUOXh-hjF12RpIOqSqz7auPiqq_Of-YFhZmYSRpXHguPX01FOcWNr104JgclVsGd_O4pebm9eV7c08enu4fF9SO1ArJIpbQCc3TCQm4BnZa5KyXkRQYFZ4ii5M5qwUBpmWlhUSuQMmNzAeXcIhNTcjb2btvmvXMhmnXTtfXw0nAFSgimRDa4YHTZtgmhdaXZtn6DbW-AmR1TMzI1A1OzY2pgyPAxEwZv_erav-b_Q9-iGXov</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Serkov, S. A.</creator><creator>Sigai, N. V.</creator><creator>Kostikova, N. N.</creator><creator>Fedorov, A. E.</creator><creator>Gazieva, G. A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220801</creationdate><title>Synthesis and evaluation of cytotoxicity of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines</title><author>Serkov, S. A. ; Sigai, N. V. ; Kostikova, N. N. ; Fedorov, A. E. ; Gazieva, G. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-44c3abae3c1bc1ae84bef41bd61d20aa3f2ec8301784683ca8714460931f9ca03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Amines</topic><topic>Aromatic compounds</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Full Articles</topic><topic>Inorganic Chemistry</topic><topic>Organic Chemistry</topic><topic>Propionic acid</topic><topic>Substitutes</topic><topic>Synthesis</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serkov, S. A.</creatorcontrib><creatorcontrib>Sigai, N. V.</creatorcontrib><creatorcontrib>Kostikova, N. N.</creatorcontrib><creatorcontrib>Fedorov, A. E.</creatorcontrib><creatorcontrib>Gazieva, G. A.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian chemical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serkov, S. A.</au><au>Sigai, N. V.</au><au>Kostikova, N. N.</au><au>Fedorov, A. E.</au><au>Gazieva, G. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and evaluation of cytotoxicity of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines</atitle><jtitle>Russian chemical bulletin</jtitle><stitle>Russ Chem Bull</stitle><date>2022-08-01</date><risdate>2022</risdate><volume>71</volume><issue>8</issue><spage>1801</spage><epage>1805</epage><pages>1801-1805</pages><issn>1066-5285</issn><eissn>1573-9171</eissn><abstract>A general and efficient method for the synthesis of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines
via
cyclocondensation of aryl(benzyl)sulfanylacetic and -propionic acids with thiosemicarbazide upon their heating in POCl
3
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| source | Springer Nature - Complete Springer Journals |
| subjects | Amines Aromatic compounds Chemistry Chemistry and Materials Science Chemistry/Food Science Full Articles Inorganic Chemistry Organic Chemistry Propionic acid Substitutes Synthesis Toxicity |
| title | Synthesis and evaluation of cytotoxicity of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines |
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