Synthesis and evaluation of cytotoxicity of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines

A general and efficient method for the synthesis of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines via cyclocondensation of aryl(benzyl)sulfanylacetic and -propionic acids with thiosemicarbazide upon their heating in POCl 3 was developed. Both aryl- and benzylsulfanilacetic and -propionic acids were successfully involved in this reaction to give the target thidiazolamines in high yields (63–98%).