Halogen-Containing 4-Hydroxybenzylidene-Rhodanines as Fast Protein Fluorogens

Halogen-Containing 4-Hydroxybenzylidene-Rhodanines as Fast Protein Fluorogens

— We report a series of ( Z )-5-(4-hydroxybenzylidene)-2-thioxothiazolidin-4-ones containing halogens at different positions of the benzylidene moiety. The new compounds exhibit fluorogenic properties and form fluorescent complexes with FAST. We showed that 3-halogen-4-hydroxybenzyliden-rhodanines c...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Russian journal of bioorganic chemistry 2022-10, Vol.48 (5), p.1105-1108
Hauptverfasser: Sokolov, A. I., Baleeva, N. S., Baranov, M. S.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Fluorescence
Halogens
Letters to the Editor
Life Sciences
Organic Chemistry
Proteins
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:— We report a series of ( Z )-5-(4-hydroxybenzylidene)-2-thioxothiazolidin-4-ones containing halogens at different positions of the benzylidene moiety. The new compounds exhibit fluorogenic properties and form fluorescent complexes with FAST. We showed that 3-halogen-4-hydroxybenzyliden-rhodanines can be used as ligands for the fluorogen-activating protein FAST in fluorescence microscopy.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162022050247